Anaerobic obligatory xylitol production in Escherichia coli strains devoid of native fermentation pathways |
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Authors: | Akinterinwa Olubolaji Cirino Patrick C |
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Institution: | Department of Chemical Engineering, Pennsylvania State University, University Park, PA 16802, USA. |
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Abstract: | Anaerobic glucose oxidation was coupled to xylose reduction in a nonfermentative Escherichia coli strain expressing NADPH-dependent xylose reductase. Xylitol production serves as the primary means of NAD(P)(+) regeneration, as glucose is converted primarily to acetate and CO(2). The membrane-bound transhydrogenase PntAB is required to achieve the maximum theoretical yield of four moles of xylitol per mole of glucose consumed. |
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