The peptidoglycan of Mycobacterium abscessus is predominantly cross-linked by L,D-transpeptidases |
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| Authors: | Lavollay Marie Fourgeaud Martine Herrmann Jean-Louis Dubost Lionel Marie Arul Gutmann Laurent Arthur Michel Mainardi Jean-Luc |
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| Affiliation: | LRMA, Equipe 12, Centre de Recherches des Cordeliers, 15 rue de l'Ecole de Médecine, 75270 Paris Cedex 06, France. jean-luc.mainardi@crc.jussieu.fr |
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| Abstract: | Few therapeutic alternatives remain for the treatment of infections due to multiresistant Mycobacterium abscessus. Here we show that the peptidoglycans of the "rough" and "smooth" morphotypes contain predominantly 3→3 cross-links generated by l,d-transpeptidases, indicating that these enzymes are attractive targets for the development of efficient drugs. |
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