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TET is targeted for proteasomal degradation by the PHD-pVHL pathway to reduce DNA hydroxymethylation
Authors:Sijia Fan  Jing Wang  Guangqing Yu  Fangjing Rong  Dawei Zhang  Chenxi Xu  Juan Du  Zhi Li  Gang Ouyang  Wuhan Xiao
Affiliation:1.State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China;2.University of Chinese Academy of Sciences, Beijing, China;3.Key Laboratory of Aquatic Biodiversity and Conservation, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China;4.Key Laboratory of Aquaculture Disease Control, Ministry of Agriculture, Wuhan, China;5.Innovation Academy of Seed Design, Chinese Academy of Sciences, Wuhan, China
Abstract:
Keywords:ubiquitylation (ubiquitination)   hydroxyproline   DNA demethylation   protein-protein interaction   E3 ubiquitin ligase   TET1   TET2   TET3   PHD2   PHD3   pVHL
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