|
|||||
|
|
TET is targeted for proteasomal degradation by the PHD-pVHL pathway to reduce DNA hydroxymethylation |
|
| Authors: | Sijia Fan Jing Wang Guangqing Yu Fangjing Rong Dawei Zhang Chenxi Xu Juan Du Zhi Li Gang Ouyang Wuhan Xiao |
| Affiliation: | 1.State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China;2.University of Chinese Academy of Sciences, Beijing, China;3.Key Laboratory of Aquatic Biodiversity and Conservation, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China;4.Key Laboratory of Aquaculture Disease Control, Ministry of Agriculture, Wuhan, China;5.Innovation Academy of Seed Design, Chinese Academy of Sciences, Wuhan, China |
| Abstract: | |
| Keywords: | ubiquitylation (ubiquitination) hydroxyproline DNA demethylation protein-protein interaction E3 ubiquitin ligase TET1 TET2 TET3 PHD2 PHD3 pVHL |