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Towards biological applications of nanophotonic tweezers
Institution:1. Department of Physics & LASSP, Cornell University, Ithaca, NY 14853, USA;2. Howard Hughes Medical Institute, Cornell University, Ithaca, NY 14853, USA;1. University of Padova, Department of Physics and Astronomy, NanoStructures Group, via Marzolo 8, I-35131 Padova, Italy;2. Departamento de Óptica, División Física Aplicada, CICESE, Ensenada, BC, Mexico;3. Instituto de Física, Universidad Nacional Autónoma de México, Circuito de la Investigación Científica, Ciudad Universitaria, Delegación Coyoacán, C.P. 04510, Ciudad de México, Mexico;1. Kazan Federal University, Kazan, 420008, Russia;2. Tatarstan Academy of Sciences, Kazan, 420111, Russia;1. Image Processing Systems Institute оf RAS, – Branch of the FSRC “Crystallography and Photonics” RAS, Samara, Russia;2. Samara National Research University, Samara, Russia;1. Institut de Biologie de L''Ecole Normale Supérieure, ENS, CNRS, INSERM, PSL Research University, Paris, France;2. Institut Jacques Monod, CNRS, Université Paris Diderot, Université de Paris, Paris, France
Abstract:Optical trapping (synonymous with optical tweezers) has become a core biophysical technique widely used for interrogating fundamental biological processes on size scales ranging from the single-molecule to the cellular level. Recent advances in nanotechnology have led to the development of ‘nanophotonic tweezers,’ an exciting new class of ‘on-chip’ optical traps. Here, we describe how nanophotonic tweezers are making optical trap technology more broadly accessible and bringing unique biosensing and manipulation capabilities to biological applications of optical trapping.
Keywords:Nanophotonic tweezers  Optical trapping  Mechanical manipulation  Biosensing  Transport  Single molecule biophysics  Lab on a chip
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