The role of interleukin-18 in pancreatitis and pancreatic cancer |
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| Institution: | 1. Department of Internal Medicine V, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg Germany;2. Department of Bone Marrow Transplantation, University Hospital Essen, Germany;3. Department of Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany;1. Section of Pulmonary Diseases, Tulane University School of Medicine, New Orleans, LA 70112, USA;2. Section of Pediatric and Adult Gastroenterology, Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA;3. Cincinnati Children''s Hospital Medical Center, Cincinnati, OH 45229, USA;4. Mikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen and Friedrich-Alexander Universität Erlangen-Nürnberg, D-91054 Erlangen, Germany |
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| Abstract: | Originally described as an interferon (IFN)-γ-inducing factor, interleukin (IL)-18 has been reported to be involved in Th1 and Th2 immune responses, as well as in activation of NK cells and macrophages. There is convincing evidence that IL-18 plays an important role in various pathologies (i.e. inflammatory diseases, cancer, chronic obstructive pulmonary disease, Crohn's disease and others). Recently, IL-18 has also been shown to execute specific effects in pancreatic diseases, including acute and chronic pancreatitis, as well as pancreatic cancer. The aim of this study was to give a profound review of recent data on the role of IL-18 and its potential as a therapeutic target in pancreatic diseases. The existing data on this topic are in part controversial and will be discussed in detail. Future studies should aim to confirm and clarify the role of IL-18 in pancreatic diseases and unravel their molecular mechanisms. |
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| Keywords: | IL-18 Acute pancreatitis Chronic pancreatitis Pancreatic cancer Progression of AP to CP CAR-T cells |
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