Loss-of-function alleles of the JIL-1 histone H3S10 kinase enhance position-effect variegation at pericentric sites in Drosophila heterochromatin |
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Authors: | Bao Xiaomin Deng Huai Johansen Jørgen Girton Jack Johansen Kristen M |
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Institution: | Department of Biochemistry, Biophysics, and Molecular Biology Iowa State University Ames, Iowa 50011, USA. |
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Abstract: | In this study we show that loss-of-function alleles of the JIL-1 histone H3S10 kinase act as enhancers of position-effect variegation at pericentric sites whereas the gain-of-function JIL-1(Su(var)3-13]) allele acts as a suppressor strongly supporting a functional role for JIL-1 in maintaining euchromatic chromatin and counteracting heterochromatic spreading and gene silencing. |
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