容量性钙内流通道的分子代表

细胞内钙库排空产生一种信号,诱导细胞膜上的钙库操纵的钙通道（SOC）开放,使Ca^2 由细胞外进入细胞内,称为容量性钙内流（CCE）,或钙释放激活的钙通道（CRAC）,可能由果蝇一过性受体电位（trp)和trp样（trpl)基因编码,钙库排空和通道开放之间的偶联机制不清,目前主要提出三种机制：（1）弥散信使;（2）蛋白质－蛋白质之间的相互作用;（3）囊泡分泌。本文综述了CCE的分子代表 ,可能机制及电生理表型。

Molecular candidates for capacitative calcium entry channel

The emptying of intracellular calcium store generates a putative signal that induces the opening of the store operated calcium channel (SOC) at the level of the cell membrane, also known as the capacitative calcium entry (CCE), or the calcium release activated calcium channel (CRAC), which allows entry of calcium into the cells from the extracellular space. Drosophila transient receptor potential (trp) and trp like(trpl) genes have been identified and reported to code cation channels(TRP and TRPL). The mechanism of coupling between store depletion and channel opening is unknown. Three fundamental mechanisms have been proposed for transmitting the signal from intracellular stores to the plasma membrane: (1) a diffusible message; (2) protein protein interactions; and (3) vesicle secretion. This review focuses primarily on the recent studies on the TRP homologues, the possible mechanisms and electrophysiological phenotypes of capacitative calcium entry.