Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish |
| |
Authors: | Thisse Christine Degrave Agnès Kryukov Gregory V Gladyshev Vadim N Obrecht-Pflumio Sophie Krol Alain Thisse Bernard Lescure Alain |
| |
Institution: | Institut de Génétique et Biologie Moléculaire et Cellulaire, CNRS/INSERM/Université Louis Pasteur, 1 rue Laurent Fries, BP 10142, CU de Strasbourg, 67404 Illkirch, France. |
| |
Abstract: | Selenium is important for embryogenesis in vertebrates but little is known about the expression patterns and biological functions of most selenoprotein genes. Taking advantage of the zebrafish model, systematic analysis of selenoprotein gene expression was performed by in situ hybridization on whole-mount embryos at different developmental stages. Twenty-one selenoprotein mRNAs were analyzed and all of them exhibited expression patterns restricted to specific tissues. Moreover, we demonstrated that highly similar selenoprotein paralogs were expressed within distinct territories. Therefore, tissue- and development-specific expression patterns provided new information for selenoproteins of unknown function. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|