Mitochondria and L-lactate metabolism |
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Authors: | Passarella Salvatore de Bari Lidia Valenti Daniela Pizzuto Roberto Paventi Gianluca Atlante Anna |
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Affiliation: | Dipartimento di Scienze per la Salute, Università del Molise, Via De Sanctis I-86100 Campobasso, Italy. |
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Abstract: | Although mitochondria have been the object of intensive study over many decades, some aspects of their metabolism remain to be fully elucidated, including the L-lactate metabolism. We review here the novel insights arisen from investigations on L-lactate metabolism in mammalian, plant and yeast mitochondria. The presence of L-lactate dehydrogenases inside mitochondria, where L-lactate enters in a carrier-mediated fashion, suggests that mitochondria play an important role in L-lactate metabolism. Functional studies have demonstrated the occurrence of several L-lactate carriers. Moreover, immunological investigations have proven the existence of monocarboxylate translocator isoforms in mitochondria. |
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