Tumor necrosis factor and interleukin-1 induce activin A gene expression in a human bone marrow stromal cell line. |
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Authors: | S Takahashi K Uchimaru K Harigaya S Asano T Yamashita |
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Institution: | Fourth Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan. |
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Abstract: | Activin A, a homodimer of the beta A chain, regulates hematopoiesis. In a human bone marrow-derived stromal cell line, KM-102, phorbol myristate acetate, tumor necrosis factor-alpha and interleukin-1 beta induced great increases in beta A chain mRNA levels and production of activin A activities. The phorbol ester-induced beta A chain gene expression was inhibited by cycloheximide and down regulation of protein kinase C, whereas the cytokine-induced expression was little affected by these treatments. These results indicate that the inflammatory cytokines directly stimulate beta A chain gene expression via protein kinase C-independent pathways. |
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