Loss of transformed phenotype upon senescence of Rous sarcoma virus-infected chicken neuroretinal cells. |
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| Authors: | G M Seigel and M F Notter |
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| Affiliation: | Department of Neurobiology and Anatomy, University of Rochester Medical Center, New York 14642. |
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| Abstract: | Success in obtaining permanent Rous sarcoma virus-infected chicken cell lines has been limited because of a senescence phenomenon. We show that a diminished, transformed phenotype, followed by dramatic morphological changes, precedes senescence. These changes are associated with continued expression of pp60v-src, as well as specific alterations in expression of two possible phosphorylated substrates of pp60v-src. |
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