Non-association of Crohn's disease with NOD2 gene variants in Moroccan patients |
| |
Authors: | Hama I Ratbi I Reggoug S Elkerch F Kharrasse G Errabih I Ouazzani H Sefiani A |
| |
Institution: | Centre de Génomique Humaine, Faculté de Médecine et de Pharmacie, Université Mohamed V Souissi, Rabat, Morocco. iman.hama@yahoo.fr |
| |
Abstract: | Crohn's disease is a chronic inflammatory bowel disease, with multifactorial traits, that can involve any part of the gastrointestinal tract. In recent years, a dozen genome-wide association scan and meta-analysis were published bringing the number of susceptibility alleles to more than 30 variations. However, the major susceptibility gene for Crohn's disease is NOD2, located on proximal 16q, which is involved in the innate immune response. Three main variants of this gene: two single nucleotide polymorphisms p.Arg702Trp and p.Gly908Arg substitutions and frameshift polymorphism p.Leu1007fsinsC are involved in susceptibility to Crohn's disease. |
| |
Keywords: | CD Crohn's disease IBD Inflammatory bowel disease NOD2 nucleotide-binding oligomerization domain containing 2 PCR Polymerase chain reaction OR Odds Ratio CI Confidence Interval |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|