|
|||||
|
|
Finding a target for resveratrol |
|
| Authors: | Tennen Ruth I Michishita-Kioi Eriko Chua Katrin F |
| Affiliation: | 1 Department of Medicine, Division of Endocrinology, Gerontology, and Metabolism, Stanford University, Stanford, CA 94305, USA 2 Geriatric Research, Education, and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA 3 R&D Division, Daiichi Sankyo Co., Ltd, 1-2-58, Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan |
| Abstract: | Despite resveratrol's well-documented health benefits, its mechanism of action remains controversial. In particular, the direct molecular target of resveratrol has been elusive. Park et?al. now show that resveratrol directly inhibits cAMP-dependent phosphodiesterases, triggering a cascade of events that converge on the important energy-sensing metabolic regulators AMPK, SIRT1, and PGC-1α. |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |