Maternal-fetal immune tolerance, block by block |
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| Authors: | Michael Gobert Juan J Lafaille |
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| Institution: | 1 Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
2 Department of Pathology, New York University School of Medicine, New York, NY 10016, USA |
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| Abstract: | How difficult is to go from egg to implanted embryo? The evolution of placentation in eutherian mammals created enormous challenges, in particular to the maternal immune system, as the fetus expresses paternal antigens that are capable of triggering immune rejection. Samstein et al. reveal a role for inducible regulatory T cells in the enforcement of maternal-fetal immune tolerance. |
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