Sibling rivalry among paralogs promotes evolution of the human brain |
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| Authors: | Tyler-Smith Chris Xue Yali |
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| Affiliation: | 1 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK |
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| Abstract: | Geneticists have long sought to identify the genetic changes that made us human, but pinpointing the functionally relevant changes has been challenging. Two papers in this issue suggest that partial duplication of SRGAP2, producing an incomplete protein that antagonizes the original, contributed to human brain evolution. |
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