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Large-scale cellular-resolution gene profiling in human neocortex reveals species-specific molecular signatures |
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| Authors: | Zeng Hongkui Shen Elaine H Hohmann John G Oh Seung Wook Bernard Amy Royall Joshua J Glattfelder Katie J Sunkin Susan M Morris John A Guillozet-Bongaarts Angela L Smith Kimberly A Ebbert Amanda J Swanson Beryl Kuan Leonard Page Damon T Overly Caroline C Lein Ed S Hawrylycz Michael J Hof Patrick R Hyde Thomas M Kleinman Joel E Jones Allan R |
| Institution: | 1 Allen Institute for Brain Science, Seattle, WA 98103, USA 2 Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA 3 Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA 4 Section on Neuropathology, Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA |
| Abstract: | Although there have been major advances in elucidating the functional biology of the human brain, relatively little is known of its cellular and molecular organization. Here we report a large-scale characterization of the expression of ～1,000 genes important for neural functions by in?situ hybridization at?a cellular resolution in visual and temporal cortices of adult human brains. These data reveal diverse gene expression patterns and remarkable conservation of each individual gene's expression among individuals (95%), cortical areas (84%), and between human and mouse (79%). A small but substantial number of genes (21%) exhibited species-differential expression. Distinct molecular signatures, comprised of genes both common between species and unique to each, were identified for each major cortical cell type. The data suggest that gene expression profile changes may contribute to differential cortical function across species, and in particular, a shift from corticosubcortical to more predominant corticocortical communications in the human brain. |
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