Thinking Outside the Synapse: Glycine at Extrasynaptic NMDA Receptors |
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| Authors: | John A Gray Roger A Nicoll |
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| Affiliation: | 1 Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
2 Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA |
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| Abstract: | In this issue, Papouin et?al. show that glycine is the endogenous coagonist for extrasynaptic NMDA receptors (NMDARs), unlike at synapses where the coagonist is d-serine. By enzymatically degrading endogenous glycine, they begin to address the enigmatic physiological and pathological roles for extrasynaptic NMDARs. |
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