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Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human |
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| Authors: | Jun Wu Pontus Boström Lauren M Sparks Li Ye Jang Hyun Choi An-Hoa Giang Melin Khandekar Kirsi A Virtanen Pirjo Nuutila Gert Schaart Kexin Huang Hua Tu Wouter D van Marken Lichtenbelt Joris Hoeks Sven Enerbäck Patrick Schrauwen Bruce M Spiegelman |
| Institution: | 1 Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02215, USA 2 Department of Human Biology, Maastricht University Medical Center, NUTRIM School for Nutrition, Toxicology, and Metabolism, Maastricht 6229 ER, The Netherlands 3 Department of Human Movement Sciences, Maastricht University Medical Center, NUTRIM School for Nutrition, Toxicology, and Metabolism, Maastricht 6229 ER, The Netherlands 4 Medical Genetics, Institute of Biomedicine, Göteborg University, Göteborg S-405 30, Sweden 5 Turku PET Center, University of Turku, Turku FI-20521, Finland 6 Lakepharma Inc., Belmont, CA 94002, USA |
| Abstract: | Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data suggest that there are two distinct types of brown fat: classical brown fat derived from a myf-5 cellular lineage and UCP1-positive cells that emerge in white fat from a non-myf-5 lineage. Here, we report the isolation of "beige" cells from murine white fat depots. Beige cells resemble white fat cells in having extremely low basal expression of UCP1, but, like classical brown fat, they respond to cyclic AMP stimulation with high UCP1 expression and respiration rates. Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin. Finally, we provide evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes. These data provide a foundation for studying this mammalian cell type with therapeutic potential. PAPERCLIP: |
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