A contractile vacuole complex is involved in osmoregulation in Trypanosoma cruzi |
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Authors: | Rohloff Peter Docampo Roberto |
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Institution: | Department of Pathobiology and Medical Scholars Program, University of Illinios at Urbana-Champaign, Urbana, IL 61801, USA. |
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Abstract: | Acidocalcisomes are dense, acidic organelles with a high concentration of phosphorus present as pyrophosphate and polyphosphate complexed with calcium and other cations. Acidocalcisomes have been linked to the contractile vacuole complex in Chlamydomonas reinhardtii, Dictyostelium discoideum, and Trypanosoma cruzi. A microtubule- and cyclic AMP-mediated fusion of acidocalcisomes to the contractile vacuole complex in T. cruzi results in translocation of aquaporin and the resulting water movement which, in addition to swelling of acidocalcisomes, is responsible for the volume reversal not accounted for by efflux of osmolytes. Polyphosphate hydrolysis occurs during hyposmotic stress, probably increasing the osmotic pressure of the contractile vacuole and facilitating water movement. |
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Keywords: | Chlamydomonas reinhardtii Dictyostelium discoideum Trypanosoma cruzi Kinetoplastida Acidocalcisomes Contractile vacuole RVD Regulatory volume decrease VSOAC Volume-sensitive organic osmolyte anion channel HAAC Hypotonically activated amino acid channel |
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