Allele Polymorphism of a New Pentanucleotide STR Marker Located to an Intron of the Tumor Suppressor Gene ING1 |
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| Authors: | T A Borodina D V Ivanov E K Khusnutdinova V A Spitsyn A V Baranova N K Yankovsky |
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| Institution: | (1) Vavilov Institute of General Genetics, Russian Academy of Science, Moscow, 117809 Russia;(2) Department of Genetics and Breeding, Moscow State University, Moscow, 119899, Russia;(3) Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Science, Ufa, 450054, Russia;(4) Medical Genetic Research Center, Russian Academy of Medical Science, Moscow, 115478, Russia |
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| Abstract: | Using polymerase chain reaction (PCR) DNA samples of unrelated subjects from the Volga-Ural region of Russia were examined to study allele polymorphism of the pentanucleotide repeat (TTGTG)
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localized to an intron of the tumor suppressor gene ING1. STR marker was registered in the EMBL database with the accession number AJ277387. In a sample of 119 individuals, three pentanucleotide alleles consisting of seven, eight, and nine repeated monomers were revealed. The allele frequencies were 0.24, 0.74, and 0.02, respectively. Heterozygosity was 0.45. On the basis of these data, the repeat can be regarded as a polymorphic STR marker for the ING1 gene and used in population and clinical studies. |
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