Interactions of liposomes with serum proteins |
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Authors: | Frederic Bont and R L Juliano |
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Institution: | Department of Pharmacology, University of Texas Medical School, Houston, TX 77025, U.S.A. |
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Abstract: | The interactions of serum proteins are diverse, complex and can lead to dramatic effects on liposome stability and in vivo behavior; conversely lipids can modify the biological activities of serum proteins. Serum lipoproteins can potentially destabilize bilayer membranes leading to vesicle disruption and loss of contents; irregularities in the lipid bilayer, such as those which exist at phase boundaries, promote the destabilizing effects of lipoproteins. Other serum components such as fibronectin, immunoglobulins and C reactive protein can modify the biological properties of liposomes by promoting interactions with reticuloendothelial cells and/or activation of the complement system. Liposomes can avidly bind certain serum clotting factors, a process which can lead to dramatic effects on the clotting cascade. Thus the interactions of liposomes with serum proteins can reciprocally effect both components involved. |
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Keywords: | serum proteins liposomes lipoproteins fibronectin clotting components |
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