A newly discovered xenobiotic metabolic pathway: ethyl ester formation. |
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Authors: | R C Chou R Wyss C A Huselton U W Wiegand |
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Institution: | Pharmaceutical Research, F. Hoffmann-La Roche Ltd, Basel, Switzerland. |
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Abstract: | Formation of etretinate, ethyl ester of acitretin, can be confirmed in vitro and in vivo using acitretin as the substrate. Etretinate was identified by LC/MS. The in vitro incubation was performed using rat and human liver 12,000 g supernatant, and the in vivo experiment was conducted in rats after oral dosing of acitretin. The ethyl ester formation was greatly enhanced by addition of or dosing with ethanol. |
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