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Protective effect of corticosteroids on intercellular junction
Authors:K Suzuki  S Higashino
Abstract:Actions of adrenocortical hormones on intercellular communication in salivary gland cells of Chironomus plumosus were studied by means of electrophysiological measurements. Glucocorticoids have an effect maintaining junctional communication, while mineralocorticoids have an effect blocking it. When glucocorticoids in their proper concentration are previously applied to the cells, they can prevent the block of junctional communication which should be produced by EGTA, lipase and trypsin. Mineralocorticoids prevail in competitive action between glucocorticoids and mineralocorticoids on junctional communication. The interaction between glucocorticoids and uncoupling agents, and between glucocorticoids and mineralocorticoids on junctional communication were discussed at the level of the cell membrane.
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