A role for glutathione as an endogenous inhibitor of the nonenzymatic decarboxylation of DOPA. |
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| Authors: | E D Mackowiak T A Hare W H Vogel |
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| Affiliation: | 1. The Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, 4 Kosciuszki St, 90-419 Lodz, Poland;2. Laboratory of Molecular Virology and Biological Chemistry, Institute of Medical Biology, Polish Academy of Sciences, 106 Lodowa St, 93-232 Lodz, Poland;3. Department of Theoretical and Structural Chemistry, Faculty of Chemistry, University of Lodz, 163/165 Pomorska St, 90-236 Łódź, Poland;4. Screening Laboratory, Institute of Medical Biology, Polish Academy of Sciences, 106 Lodowa St, 93-232 Lodz, Poland;1. Department of Environmental Analysis, Faculty of Chemistry, University of Gdańsk, ul. Wita Stwosza 63, PL-80-308 Gdańsk, Poland;2. BAM Federal Institute for Materials Research and Testing, Unter den Eichen 87, 12205, Berlin, Germany;3. Department of Organic Chemistry, Faculty of Chemistry, University of Gdańsk, ul. Wita Stwosza 63, PL-80-308 Gdańsk, Poland |
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| Abstract: | The aromatic l-amino acid (DOPA) is an important precursor in the formation of neurotransmitter substances (1) and of melanin (2). In both reactions, decarboxylation of DOPA is involved. Decarboxylation can occur enzymatically (3) or nonenzymatically (4,5). In most tissues nonenzymatic decarboxylation is inhibited by the presence of an unidentified endogenous inhibitor (6,7,8). In this study we have identified glutathione as a potential endogenous inhibitor of the nonenzymatic decarboxylation reaction. |
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