Transient forebrain ischemia increases the blood-brain barrier permeability for albumin in stroke-prone spontaneously hypertensive rats |
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Authors: | Abrahám Csongor S Harada Noboru Deli Mária A Niwa Masami |
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Institution: | (1) Department of Pharmacology 1, Nagasaki University School of Medicine, Sakamoto, Nagasaki, Japan |
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Abstract: | 1. The aim of the present study was to reveal the effect of transient forebrain ischemia on the regional and temporal changes in the permeability of the blood-brain barrier (BBB) permeability for sodium fluorescein (MW: 376 Da) and Evan's blue-labeled albumin (MW: 67 kDa) in stroke-prone spontaneously hypertensive rats (SHRSP).2. BBB permeability was significantly higher in the brain regions of 16-week-old control SHRSP than those in age-matched normotensive Wistar-Kyoto rats.3. Transient forebrain ischemia evoked by 10-min bilateral carotid occlusion increased the permeability of the BBB for albumin, but not for sodium fluorescein, after 6 and 24 h of reperfusion in brain regions of SHRSP.4. Extravasation of serum macromolecules may contribute to neuronal loss and development of hypertensive encephalopathy in SHRSP. |
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Keywords: | blood-brain barrier permeability cerebral ischemia-reperfusion Evan's blue-albumin sodium fluorescein stroke-prone spontaneously hypertensive rat |
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