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Biotransformations of aryl alkyl sulfides by whole cells of white-rot Basidiomycetes |
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| Authors: | Luí s C. Ricci, Jo o V. Comasseto, Leandro H. Andrade, Marina Capelari, Quezia B. Cass,Andr L.M. Porto |
| Affiliation: | aLaboratório de Química Fina e Biocatálise, Instituto de Química, Universidade de São Paulo – USP, Av. Prof. Lineu Prestes 748, CEP 05508-900 São Paulo, SP, Brazil bInstituto de Botânica, Seção de Micologia e Liquenologia, Av. Miguel Estéfano, CP 4005, CEP 01061-970 São Paulo, SP, Brazil cUniversidade Federal de São Carlos, Departamento de Química, CP 676, CEP 13565-905 São Carlos, SP, Brazil |
| Abstract: | White-rot Basidiomycetes promoted the oxidation of aromatic pro-chiral sulfides into sulfoxides with good enantioselectivity, conversion and a small production of sulfones. The reactions were carried out using whole cells of Irpex lacteus, Pycnoporus sanguineus, Trichaptum byssogenum, Trametes rigida, Trametes versicolor and Trametes villosa. The enantioselectivity for all the aryl alkyl sulfoxides was in favor of (S)-enantiomers. Oxidation of (phenylpropyl)sulfide produced (S)-(phenylpropyl)sulfoxide with high enantiomeric excess (e.e. ≥99%) by all the Basidiomycetes employed. Basidiomycetes isolated from Brazilian biomes were used as biocatalysts in the oxidation reaction. |
| Keywords: | Basidiomycetes Oxidation Whole fungal cells Chiral sulfoxides |
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