大头金蝇幼虫油脂对小鼠的降血脂作用

用健康昆明种小鼠建立高脂血症模型，同时用不同剂量的大头金蝇Chrysomyia megacepha la (Fabricius)幼虫油脂灌胃5周，摘除眼球取血，用试剂盒检测血脂值，光学显微镜观察小鼠肝脏病理变化。结果表明：大头金蝇幼虫油脂处理组小鼠血清胆固醇(TC)、甘油三酯（TG）、低密度脂蛋白胆固醇(LDL-C)水平显著降低，低剂量、中剂量和高剂量油脂处理组小鼠TG的浓度较高脂模型组小鼠分别下降20.70%、48.98%和56.06%；高脂模型组小鼠血清TC高达4.59 mmol/L，低剂量、中剂量和高剂量油脂处理组小鼠TC浓度较高脂模型组小鼠分别下降16.99%、23.52%和25.49%；高密度脂蛋白胆固醇（HDL-C）升高明显，低剂量、中剂量和高剂量油脂处理组小鼠HDL-C较高脂模型组小鼠升高11.74%、18.04%和18.95%，并呈现一定的剂量-效应关系；连续饲喂大头金蝇幼虫油脂对小鼠肝细胞有一定保护作用。提示大头金蝇幼虫油脂具有治疗小鼠高脂血症的作用。

Effect of oil from Chrysomyia megacephala (Fabricius) larvae in reducing blood lipids of mice

Effect of larval oil of Chrysomyia megacephala (Fabricius) on hyperlipemia was studied. Hyperlipemia model was established in mice. The oil in different dose was garaged to the mice for 5 weeks. Blood samples were sampled. The levels of blood lipids were detected. The pathological changes in the liver were observed microscopically. The results showed that larval oil of C. megacephala could obviously reduce contents of triglyceride (TC), TG, and low-density lipoprotein cholesterol (LDL-C) (P<0.05 or P<0.01). Compared to the concentration of total cholesterin (TG) in HFD group model, the concentration of TG in low dose group, medium dose group and high dose group decreased by 20.70%, 48.98% and 56.06%, respectively. The concentration of TC in serum in HFD group model was 4.59 mmol/L. The concentration of TC in larva oil of C. megacephala in low dose group, medium dose group, and high dose group decreased by 16.99%, 23.52% and 25.49% compared with that of TC in HFD group model respectively. HDL-C increased significantly (P<0.05): the concentrations of HDL-C in low dose group, medium dose group and high dose group increased by 11.74%, 18.04% and 18.95% compared with that of HDL-C in HFD group model, respectively. The increase of HDL-C (P<0.05) in serum showed a relationship between the quantity and the effect. Successfully feeding the mice with larva oil of C. megacephala had a protection effect to the liver cells. The results suggest that larval oil of C. megacephala may have a therapeutic effect on hyperlipemia.