The C57BL/6 nude, beige mouse: a model of combined T cell and NK effector cell immunodeficiency |
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| Authors: | F Pflumio P Fonteneau C Gavériaux S Cammisuli F Loor |
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| Institution: | Laboratory of Immunology, Louis Pasteur University Strasbourg 1, Illkirch, France. |
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| Abstract: | This article describes the construction and establishment of a double congenic nude, beige C57BL/6 (B6 nu, bg) mouse strain. The mice do not show higher fragility than C57BL/6 nude mice and the double congenic strain can be maintained under conventional mouse housing conditions. Although the B6 nu, bg display a very low natural killer activity which cannot be enhanced by an interferon inducer (poly(I-C], they lack responsiveness to a T cell mitogen (concanavalin A); and they also show extremely low responsiveness to a B cell mitogen (0128: B12 Escherichia coli lipopolysaccharide) probably as a result of combined effects of the beige and nude genes in the C57BL/6 genetic context. |
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