Hotspots of homologous recombination in the human genome: not all homologous sequences are equal |
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| Authors: | James R Lupski |
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| Affiliation: | (1) Departments of Molecular and Human Genetics, Baylor College of Medicine, 77030 Houston, TX, USA;(2) (sabbatical until July 2005): Wellcome Trust Sanger Institute, CB10 ISA Hinxton, Cambridge, UK |
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| Abstract: | Homologous recombination between alleles or non-allelic paralogous sequences does not occur uniformly but is concentrated in 'hotspots' with high recombination rates. Recent studies of these hotspots show that they do not share common sequence motifs, but they do have other features in common. |
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