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Activity of sodium trimetaphosphate,associated or not with fluoride,on dual-species biofilms
Authors:Thamires Priscila Cavazana  Thayse Yumi Hosida  Juliano Pelim Pessan  Caio Sampaio  Douglas Roberto Monteiro
Institution:Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea
Abstract:Abstract

A response surface methodology was used to build a model to predict reductions in uropathogenic Escherichia coli biofilms in response to three compounds: cranberry extract CB] at 3.0–9.0%, and caprylic acid CAR] and thymol TM] at 0.01%–0.05%. The predictive model for microbial reduction had a high regression coefficient (R2?=?0.9988), and the accuracy of the model was verified (R2?=?0.9527). Values of CAR, TM, and the quadratic term CAR2 were the most significant (P?10 reduction) determined by ridge analysis were 8.3% CB +0.04% CAR +0.04% TM at 37?°C for 1?min. The model could be used to predict the most cost-efficient amounts of antimicrobial agents for anti-urinary tract infection products such as catheter lock solution and antimicrobial coatings for catheters.
Keywords:Biofilms  Streptococcus mutans  Candida albicans  phosphate  fluorides
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