CTLA4 gene polymorphisms are associated with, and linked to, insulin-dependent diabetes mellitus in a Russian population |
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| Authors: | Dimitry A Chistiakov Kirill V Savost'anov Valery V Nosikov |
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| Affiliation: | (1) INSERM U36, College de France, 75231, Paris Cedex 05, France;(2) Department of Molecular Diagnostics, National Research Center GosNIIgenetika, 113545, Moscow, Russia |
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| Abstract: | Background The association between the human cytotoxic T lymphocyte-associated antigen-4 (CTLA4) gene and insulin-dependent diabetes mellitus (IDDM) is unclear in populations. We therefore investigated whether the gene conferred susceptibility to IDDM in a Russian population. We studied two polymorphic regions of the CTLA4 gene, the codon 17 dimorphism and the (AT)n microsatellite marker in the 3' untranslated region in 56 discordant sibling pairs and in 33 identical by descent (IBD) affected sibships. |
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