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Elevated Na+/H+ exchange in erythrocytes of patients with hypertension |
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| Authors: | S N Orlov I Iu Postnov N I Pokudin V Iu Kukharenko |
| Abstract: | The kinetics of proton efflux from erythrocytes with acidified cytoplasm (pHi 6.4) in a medium with pH 8.0 has been studied. The participation of the anion exchanger in this process was blocked by a stilbene disulfonic acid derivative. It was shown that the rate of Na+/H+ exchange (amiloride-inhibited component of proton efflux) is increased 2 fold. The addition of protein kinase C activator (1 microM of TPA) results in the increase of the rate of Na+/H+ exchange by 4 fold. |
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