Polymer-supported biopolymer synthesis: 1. High load solid (gel) phase strategy for peptide synthesis with a phenolic poly(acryloylmorpholine)-based support |
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Authors: | R Epton P Goddard SJ Hocart G Marr D Hudson |
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Institution: | Department of Physical Sciences, Wolverhampton Polytechnic, Wulfruna Street Wolverhampton WV1 ILY, UK;Biosearch, 1281 F Anderson Drive, San Rafael, California 94901, USA |
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Abstract: | An efficient, low-cost, reaction strategy for the solid (gel) phase synthesis of peptides and protected peptide segments has been developed. The strategy involves the use of a new poly(acryloylmorpholine)-based phenolic support matrix, Koch-Light Peptide Resin A. Illustrative syntheses of N-terminal Boc- and Z-protectedLeu]- enkephalin derivatives, including C-terminal acid hydrazides and esters, are described. The strategy, which is effective for the synthesis of peptides at high matrix loadings, is adopted readily for large-scale application. |
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Keywords: | Phenolic resins peptide synthesis solid (gel) phase poly(acryloylmorpholine) |
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