布洛芬联合甲硝唑对慢性牙周炎龈沟液中细胞因子的影响

目的:研究布洛芬联合甲硝唑对慢性牙周炎的疗效和对龈沟液中细胞因子的影响。方法:选择2013年1月~2015年12月在我院进行诊治的慢性牙周炎患者82例,随机分为两组,观察组给予布洛芬联合甲硝唑治疗,对照组给予甲硝唑治疗,比较两组的临床疗效、龈沟液中细胞因子的变化和抗氧化作用。结果:观察组的有效率为82.93%(34/41),明显高于对照组的65.85%(27/41)(P0.05);两组治疗后的龈沟出血指数、牙菌斑指数、附着水平和牙周袋深度均明显降低(P0.05),且观察组降低的更为明显(P0.05);两组治疗后的超敏C反应蛋白、肿瘤坏死因子、白介素-6和白介素-8水平均明显降低(P0.05),且观察组降低的更为明显(P0.05);两组治疗后的超氧化物歧化酶和谷胱甘肽过氧化物酶水平均明显升高(P0.05),丙二醛和一氧化氮水平均明显降低(P0.05),且观察组更为明显(P0.05);两组不良反应发生率相比无明显差异(P0.05)。结论:布洛芬联合甲硝唑对慢性牙周炎疗效显著,可以有效降低炎症水平,减少自由基损伤,有助于牙周组织的重建及恢复。

Effect of Ibuprofen Combined with Metronidazole on Cytokines in Gingival Sulcus Fluid of Chronic Periodontitis

ABSTRACT Objective: To study the effect of ibuprofen combined with metronidazole on chronic periodontitis and cytokines in gin- gival sulcus fluid. Methods: 82patients with chronic periodontitis who were treated in our hospital from January 2013 to December 2015were selected and divided into two groups randomly. The patients in observation group were treated with ibuprofen combined with metronidazole, and the patients in control group were treated with metronidazole. The curative effect, the changes of cytokines in gingival sulcus fluid and the antioxidation effect were compared. Results: After treatment, the effective rate of the observation group was 82.93%(34/41), significantly higher than 65.85%(27/41) of the control group(P<0.05); sulcus bleeding index, dental plaque index, attachment loss, depth of pocket were significantly decreased (P<0.05), and it was decreased more significantly in observation group (P<0.05); the superoxide discrimination enzymes and glutathione peroxidase levels were significantly increased (P<0.05), malondialdehyde and nitric oxide levels were significantly reduced (P<0.05), and it was more significantly observation group(P<0.05); the adverse reactions of two groups had no significant difference (P>0.05). Conclusion: Ibuprofen combined with metronidazole have significant effect on chronic periodontitis, which can effectively reduce the level of inflammation, reduce free radical damage, and contribute to the reconstruction and recovery of periodontal tissue.