清胰利胆颗粒对重症急性胰腺炎患者血清HMGB1, HSP70, HSP27,IL-8水平的影响

目的:研究清胰利胆颗粒对重症急性胰腺炎患者血清高迁移率族蛋白1(HMGB1)、热休克蛋白70(HSP70)、热休克蛋白27(HSP27)、白介素-8(IL-8)水平的影响。方法:选取2015年8月至2016年7月我院收治的84例重症急性胰腺炎患者,根据随机数字法分为观察组和对照组,42例每组。对照组采取常规方案完成治疗,观察组在此基础上使用清胰利胆颗粒治疗。比较两组患者临床疗效,血淀粉酶恢复至正常时间、白细胞恢复至正常时间、胃肠功能恢复至正常时间、腹痛缓解时间及血清HMGB1、HSP70、HSP72、IL-8水平。结果:治疗后,观察组临床总有效率显著高于对照组[92.86%(39/42)比71.43%(30/42)](P0.05)。观察组的血淀粉酶恢复至正常时间、白细胞恢复至正常时间、胃肠功能恢复至正常时间及腹痛缓解时间显著短于对照组(P0.05)。治疗前,两组患者HMGB1、HSP70、HSP72、IL-8水平比较无显著差异(P0.05),治疗后,两组患者HMGB1、HSP70、HSP72、IL-8水平和治疗前相比显著下降(P0.05),和对照组相比,观察组的HMGB1、HSP70、HSP72、IL-8水平较低(P0.05)。结论:清胰利胆颗粒能有效降低重症急性胰腺炎患者血清HMGB1、HSP70、HSP27、IL-8水平,且可提高临床疗效。

Effect of Qingyi Lidan Granule on Serum Levels of HMGB1, HSP70, HSP27 and IL-8 of Patients with Severe Acute Pancreatitis

ABSTRACT Objective: To study the effect of Qingyi Lidan Granule on the serum levels of high mobility group box 1 (HMGB1), heat shock protein 70 (HSP70), heat shock protein 27(HSP27) and interleukin-8 (IL-8) of patients with severe acute pancreatitis. Methods: From August 2015 to July 2016, 84 patients with severe acute pancreatitis in our hospital were selected and randomly divided into the observation group and the control group according to random number, 42 cases in each group. The control group was given routine treatment, and the observation group was treated by Qingyi Lidan Granule on the basis of control group. The recovery of blood amylase to normal time, white blood cell recovery to normal time, recovery of gastrointestinal function to normal time and relieving time of abdominal pain, serum levels of HMGB1, HSP70, HSP72 and IL-8 in both groups were observed and compared before and after treatment. Results: After treatment, the total clinical effective rate of observation group was significantly higher than that of the control group[92.86% (39/42) vs 71.43% (30/42)] (P<0.05). The recovery of blood amylase to normal time, white blood cell recovery to normal time, recovery of gastrointestinal function to normal time and relieving time of abdominal pain in the observation group were significantly shorter than those of the control group (P <0.05). Before treatment, no significant difference was found in the serum levels of HMGB1, HSP70, HSP72, IL-8 between groups(P>0.05). After treatment, the serum levels of HMGB1, HSP70, HSP72 and IL-8 in both groups were significantly lower than those before treatment (P<0.05). The levels of HMGB1, HSP70, HSP72 and IL-8 in the observation group were lower than those in the control group (P<0.05). Conclusion: Qingyi Lidan Granule could effectively reduce the levels of serum HMGB1, HSP70, HSP27 and IL-8 and enhance the clinical curative effect of patients with severe acute pancreatitis.