儿童过敏性紫癜合并消化道出血的影响因素分析

目的:探讨过敏性紫癜合并消化道出血的相关危险因素。方法:回顾性分析2013年9月至2016年6月在武汉协和医院儿科住院治疗的80例过敏性紫癜初诊患儿的临床资料,根据是否合并消化道出血分为消化道出血组11例,非消化道出血组69例,比较两组患儿的年龄、地区、性别、发病季节、紫癜分布特征、是否合并紫癜性肾炎、hsCRP、ESR、血常规、生化等。结果:与非消化道出血组相比,消化道出血组患儿的发病季节、血清超敏C反应蛋白(hsCRP)、血清钙离子(Ca)水平差异均有统计学意义(P0.05),两组紫癜性肾炎发病率比较差异无统计学意义,但消化道出血组合并紫癜性肾炎的比例(45.5%)明显高于非消化道出血组(21.7%)。结论:夏冬季节、高水平血清CRP、低水平血清Ca~(2+)是过敏性紫癜患儿合并消化道出血的危险因素。

A Retrospective Analysis of the Risk Factors of Henoch-Schonlein Purpura with Alimentary Tract Hemorrhage in Children

ABSTRACT Objective: To investigate related risk factors of allergic purpura complicated with alimentary tract hemorrhage in children. Methods: The clinical data of 80 cases of allergic purpura in newly diagnosed children from September 2013 to June 2016 who hospitalized in the pediatrician of Wuhan Union Hospital were retrospectively analyzed. According to complication with alimentary tract hemorrhage, these cases were divided into two groups: 11 cases of alimentary tract hemorrhage group and 69 cases of non-alimentary tract hemorrhage group. The age, region, sex, onset season, the distribution of purpura, the combination of purpura nephritis, C-reactive protein, erythrocyte sedimentation rate, blood routine, biochemistry of were compared between two groups. Results: Compared with non-alimentary tract hemorrhage group, the levels of serum high-sensitivity C-reactive protein (hsCRP) and serum calcium (Ca) were significantly different in alimentary tract hemorrhage group (P <0.05). There was no significant difference in the incidence of purpura nephritis between these two groups. The proportion of purpura nephritis in alimentary tract hemorrhage group was 45.5% which was obviously higher than 21.7 % in non-alimentary tract hemorrhage group. Conclusion: Summer and winter season, high levels of serum CRP, and low serum Ca²⁺ are risk factors of allergic purpura complicated with alimentary tract hemorrhage in children.