血清VEGF，IGF-1和CA125水平与子宫动脉栓塞术(UAE)治疗子宫腺肌症的相关性

目的:探讨血清血管内皮生长因子(VEGF)、胰岛素样生长因子-1(IGF-1)和CA125水平和子宫动脉栓塞术(UAE)治疗子宫腺肌症的之间的相关性。方法:选择接受子宫动脉栓塞术治疗的39例子宫腺肌症患者作为患者组,取同时期参加健康体检的30名健康者作为健康对照组。用ELISA法检测子宫腺肌症患者子宫动脉栓塞术前和术后不同时点血清VEGF、IGF-1、CA125的水平,评估子宫动脉栓塞术后的患者的疗效。结果:34例痛经患者术后1个月开始改善,最终29例完全缓解,有效率85.2%。患者组治疗前血清VEGF、IGF-1、CA125水平均显著高于健康对照组(P0.05)。子宫动脉栓塞术治疗后,患者组血清IGF-1、VEGF和CA125的水平与治疗前相比均显著降低,术后6月,恢复正常水平。结论:血清IGF-1、VEGF、CA125的变化可能在子宫动脉栓塞术治疗子宫腺肌症中作为疗效和预后评估指标。

Clinical Significance of Serum VEGF, IGF-1 and CA125 Levels in the Uterine Artery Embolization Treatment for Uterine Adenomyosis

ABSTRACT Objective: To investigate the correlation of serum concentration of vascular endothelial growth factor (VEGF), in- sulin-like growth factor 1 (IGF 1) and CA125 with uterine artery embolization (UAE) in the treatment of uterine adenomyosis. Methods: 39 cases of uterine adenomyosis patients were chosen as patient group and received uterine artery embolization, 30 healthy subjects were selected as control. The serum concentrations of VEGF, IGF 1, CA125 before and after the operation were quantified by ELISA at differ- ent time points. The curative effect after uterine artery embolization was evaluated. Results: After 1 month of UAE, in 34 patients with dysmenorrhea, 29 cases turned to be complete remission with its final efficiency of 85.2%. The VEGF, IGF 1 and CA125 concentrations in serum of patient group were significantly higher than those of normal control group before UAE treatment (P<0.05). After uterine artery embolization, the serum concentrations of IGF 1, VEGF and CA125 of patient group decreased significantly. After 6 months of UAE treatment, all indicators turned to be at normal level. Conclusion: The changes of serum IGF - 1, VEGF and CA125 concentrations could be taken as curative effect and prognosis marker of uterine artery embolization in the treatment of uterine adenomyosis.