黄芩汤药效物质基础及其治疗胃肠道疾病研究进展

黄芩汤是《伤寒论》中治疗下痢的经典方剂,由黄芩、芍药、甘草(炙)和大枣四味中药煎煮而成,用于治疗痢疾、腹泻等胃肠道疾病已有近1800年,中药治疗胃肠道疾病相较于西药更安全。本文结合国内外相关文献,对近几年来黄芩汤药效物质基础研究进行概括总结,并对其治疗溃疡性结肠炎和减轻化疗药物胃肠道毒性机制的最新研究进行了综述,结合胃肠道疾病的发病机制以及黄芩汤减毒机制的研究方法对现有研究过程中存在的不足进行了评述,并对中药疗效研究展开设想,提出以组学作为研究手段,配合中药复方整体作用模式的组分-疗效研究思路,以期为黄芩汤治疗胃肠道疾病的研究提供参考。

Progress in Pharmacodynamic Material Basis and Treatment for Gastrointestinal Diseases of Huangqin Decoction

ABSTRACT: Huangqin Decoction is a classic recipe for treatment of diarrhea from Treatise on Exogenous Febrile Disease, and consists of Scutellaria baicalensis, Paeonia lactiflora, Glycyrrhiza uralensis and Ziziphus jujuba. Huangqin Decoction has been used for nearly 1800 years for the treatment of gastrointestinal ailments, including dysentery, diarrhea and so on. Treatment of gastrointestinal dis- ease by traditional Chinese medicine is considered to be safer than western medicine. This paper presented a review of pharmacodynamic material basis of Huangqin Decoction, its advances in treating ulcerative colitis and reduction of the gastrointestinal side effects arising from chemotherapy drugs according to related literature. It also reviewed the deficiencies in present research, outlined the future direction and provided reference for further study.