肝组织弥散度成像在慢性肝损伤诊断中的临床研究

目的:探讨Strain Histogram组织弥散度成像技术在慢性肝损伤程度无创诊断中的临床价值。方法:应用Strain Histogram组织弥散度成像技术定量检测180例慢性肝炎(病毒性肝炎105例,非病毒性肝炎75例)患者肝脏弹性特征值,对照病理,分析肝脏弹性特征值与肝纤维化及肝脏炎症程度的相关性。结果:180例慢性肝炎患者LF指数用于判断轻度与中重度纤维化的诊断界值为2.785,LF指数越大,纤维化程度越重,灵敏度76.6%,特异度48.9%;LF指数用于判断轻度与中重度炎症的诊断界值为2.925,LF指数越大,炎症程度越重,灵敏度73.2%,特异度56.8%。105例病毒性肝炎患者LF指数用于判断轻度与中重度纤维化的诊断界值为2.975,LF指数越大,纤维化程度越重,灵敏度69.2%,特异度67.1%;LF指数用于判断轻度与中重度炎症的诊断界值为2.915,LF指数越大,炎症程度越重,灵敏度80.0%,特异度57.8%。75例非病毒性肝炎患者LF指数与肝纤维化和炎症程度不具有相关性。结论:LF指数可以反映肝脏纤维化及炎症程度,诊断灵敏度高,LF指数越大,肝纤维化及炎症程度越重。

Clinical Study of Liver Tissue Dispersion Imaging in Diagnosis of Chronic Liver Injury

ABSTRACT Objective: To investigate the clinical value of Histogram Strain tissue dispersion imaging in noninvasive diagnosis of chronic liver injury. Methods: Liver elasticity of 180 patients with chronic hepatitis (105 viral hepatitis and 75 non-viral hepatitis) was quantitatively detected by elastic imaging technique. The correlation between liver elasticity characteristic value and liver fibrosis and in- flammation degree were analyzed. Results: The LF diagnostic cut-off value in differentiating mild and moderate to severe fibrosis in 180 chronic hepatitis patients was 2.785, with a sensitivity of 76.6% and specificity 48.9%. The LF diagnostic cut-off value in differentiating mild and moderate to severe inflammation in 180 chronic hepatitis patients was 2.925, with a sensitivity of 73.2% and specificity 56.8%. The LF diagnostic cut-off value in differentiating mild and moderate to severe fibrosis in 105 viral hepatitis patients was 2.975, with a sensitivity of 69.2% and specificity 67.1%. The LF diagnostic cut-off value in differentiating mild and moderate to severe inflammation in 105 viral hepatitis patients was 2.915, with a sensitivity of 80.0% and specificity 57.8%. The LF index was not correlated with degrees of liver fibrosis and inflammation in 75 non-viral hepatitis patients. Conclusion: LF index can reflect the degree of liver fibrosis and inflam- mation, the higher the diagnostic sensitivity, the greater the LF index, the more severe liver fibrosis and the degree of inflammation.