青蒿素类化合物与肥胖诱导的代谢性炎症

青蒿素类化合物是治疗疟疾的首选药物，具有高效、速效、低毒和安全的特点。近三十年来，大量研究结果证明青蒿素类化合物具有抗炎和免疫调节功能；这些研究主要集中于自身免疫性疾病，如类风湿性关节炎、全身性红斑狼疮、哮喘病和过敏反应等。最新研究表明，青蒿素类化合物可通过促进白色脂肪棕色化和增强棕色脂肪功能，起到预防肥胖的作用。作为肥胖过程中免疫细胞和炎症状况变化显著的脂肪组织，青蒿素类化合物是否参与其中的免疫炎症调节以及在该过程中发挥的潜在作用有待进一步实验的验证。本文对已有的青蒿素类化合物在抗炎和免疫调节方面的报道进行总结，并对青蒿素类化合物在改善肥胖诱导代谢性炎症方面的潜在应用进行展望。

Immune Functions of Artemisinin Derivatives in Amelioration of Obesity-Induced Metabolic Inflammation

As the first-line antimalarial drugs in the world, artemisinin and its bioactive derivatives are considered high and fast effectiveness, low toxicity and safety. In the last three decades, accumulating evidences have revealed that artemisinins possess potent anti inflammatory and immunoregulatory properties, and most of these studies are focused on the autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, asthma and allergic diseases. Recent researches, however, have made an intriguing role of artemisinins in preventing obesity by inducing browning of white fat and enhancing brown fat function. Adipose tissue undergoes significant changes in terms of immune cell and inflammatory state during the progress of obesity. The potential function of artemisinins in obesity related immune regulation needs more experimental exploration. Here we provide a comprehensive summary on the reports of artemisinin and its derivatives affecting inflammation and immune response and get a promising perspective of the potential application of artemisinins in ameliorating obesity induced metabolic inflammation.