腹腔镜胆囊切除术对急性化脓性胆囊炎患者血清SOD,MDA及肝功能的影响

目的:探讨腹腔镜胆囊切除术治疗急性化脓性胆囊炎的疗效及对患者血清超氧化物歧化酶(SOD)、丙二醛(MDA)及肝功能的影响。方法:选择2014年9月至2016年9月我院接诊的92例急性化脓性胆囊炎患者,随机分为观察组(n=46)和对照组(n=46),对照组使用传统开腹式胆囊切除术,观察组使用腹腔镜下胆囊切除术。观察并比较两组患者的术中出血量、术后引流量、手术时间、术后排气时间及住院时间,治疗前后丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、超氧化物歧化酶(SOD)及丙二醛(MDA)水平,以及术后并发症的发生情况。结果:观察组术中出血量、术后引流量少于对照组,手术时间、术后排气时间、排便时间、住院时间均比对照组短(P0.05);手术后,观察组丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)水平均比对照组低(P0.05);观察组超氧化物歧化酶(SOD)水平高于对照组,丙二醛(MDA)水平低于对照组(P0.05);观察组术后并发症总发生率低于对照组(P0.05)。结论:腹腔镜胆囊切除术治疗急性化脓性胆囊炎的效果显著,对患者肝功能损伤较小,术后并发症少,值得临床应用推广。

Effects of Laparoscope Cholecystectomy on Serum Levels of SOD and MDA and Liver Functions of Patients with Acute Suppurative Cholecystitis

ABSTRACT Objective: To study the effects of laparoscope cholecystectomy on serum levels of superoxide dismutase (SOD) and malondialdehyde (MDA) and liver functions of patients with acute suppurative cholecystitis and its curative effects. Methods: 92 patients with acute suppurative cholecystitis who were treated in our hospital from September 2014 to September 2016 were selected and randomly divided into the observation group (n=46) and the control group (n=46). The patients in the control group were treated with the conventional cholecystectomy, while the patients in the observation group were treated with laparoscope cholecystectomy. Then the blood loss, the operation time, postoperative drainage volume, the exhaust time and hospitalization, the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), superoxide dismutase (SOD) and malondialdehyde (MDA) and the complications were observed and compared between the two groups before and after the operation. Results: The blood loss and postoperative drainage volume in the observation group were lower than those of the control group, and the the operation time, postoperative exhaust time, defecation time and hospitalization were shorter than those of the control group (P<0.05); After the operation, the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBIL) in the observation group were lower than those of the control group (P<0.05); After the operation, the serum levels of SOD in the observation group was higher than that of the control group, while the MDA was lower (P<0.05); The incidence of postoperative complications in the observation group was lower than that of the control group (P<0.05). Conclusion: Laparoscope cholecystectomy has obvious clinical effects on the treatment of acute suppurative cholecystitis, with less damage to liver functions and lower incidence of postoperative complications, which is worthy of clinical application.