腹腔镜膀胱癌根治术的临床疗效及对患者血清SF, SIL-2R及TSGF水平的影响

目的:分析腹腔镜膀胱癌根治术的临床疗效及对血清铁蛋白(SF)、可溶性白介素-2受体(SIL-2R)、肿瘤特异性生长因子(TSGF)的影响。方法:选择2012年8月~2016年2月于我院就诊的98例膀胱癌患者,参照抽签法分作对照组(n=49)与研究组(n=49),对照组采用开放性膀胱癌根治术治疗,研究组采用腹腔镜膀胱癌根治术治疗,观察两组手术时间、术中出血量、肛门排气时间、住院时间、淋巴结清扫数目,SF、SIL-2R、TSGF,白细胞数、皮质醇,并发症率及复发率。结果:研究组手术时间多于对照组,研究组术中出血量、肛门排气时间、住院时间均少于对照组,组间差异有统计学意义(P0.05)。两组淋巴结清扫数目、复发率比较无差异(P0.05)。术后,两组SF、SIL-2R、TSGF均降低,组间比较无差异(P0.05),两组白细胞数、皮质醇均上升,研究组低于对照组(P0.05)。结论:LRC与ORC的临床疗效相似,均可降低血清SF、SIL-2R、TSGF水平,但LRC的创伤较小,在严格掌握适应症的情况下可作为膀胱癌的首选方式。

Clinical Effect of Laparoscopic Radical Prostatectomy Bladder Cancer and the Influence on Serum Levels of SF, SIL-2R and TSGF

ABSTRACT Objective: To analysis clinical curative effect of laparoscopic radical prostatectomy bladder cancer and influence on serum levels of ferritin (SF), soluble interleukin-2 receptor (SIL-2 R) and tumor specific growth factor (TSGF). Methods: 98 cases of bladder cancer who were treated in our hospital from August 2012 to February 2016 were selected and randomly divided into the control group (n=49) and the research group (n=49). The patients in the control group were treated with open radical radical cystectomy, while the patients in the research group were treated with laparoscopic radical cystectomy. Then the operation time, intraoperative blood loss, anal exhaust time, hospitalization, the lymph node cleaning, the serum levels of SF, SIL-2R, TSGF, white blood cells and cortisol, the complications and recurrence rate in the two groups were observed and compared. Results: The operation time of research group was longer than that of the control group, while the intraoperative blood loss, the hospitalization and the anal exhaust time were less than those of the control group, and the differences were statistically significant (P<0.05). There was no statistically significant difference about the numbers of the lymph node and the recurrence rate between two groups (P<0.05). After treatment, the serum levels of SF, SIL-2R and TSGF in the two groups decreased, while there was no statistically significant difference between the two groups (P>0.05); After treatment, the white blood cell count and cortisol rise in the two groups increased, while the research group was lower than that of the control group (P<0.05). Conclusion: LRC and ORC clinical efficacy similar, both of which can reduce the serum levels of SF, SIL-2R and TSGF of patients with laparoscopic radical prostatectomy bladder cancer.