自拟益气活血方治疗小儿脾肾气虚型肾病综合征的疗效观察

目的:探讨自拟益气活血方治疗小儿脾肾气虚型肾病综合征的临床疗效。方法:选择2014年6月到2016年10月我院收治的80例脾肾气虚型肾病综合征患儿,按随机数字表法分为对照组和治疗组各40例。对照组给予强的松治疗,治疗组在对照组治疗的基础上给予自拟益气活血方治疗,两组均治疗4个月。评估两组临床疗效,检测治疗前后两组24h尿蛋白、总胆固醇(TC)、血浆白蛋白(Alb)以及肾功能指标包括尿素氮(BUN)、血肌酐(Scr)、血肌酐清除率(Ccr)。结果:治疗组的总有效率为95.00%,明显高于对照组的67.50%,差异具有统计学意义(P0.05)。治疗后,两组24 h尿蛋白、TC、BUN及Scr水平低于治疗前,Alb、Ccr水平高于治疗前,且治疗组上述各指标水平变化均显著优于对照组,差异均具有统计学意义(P0.05)。结论:自拟益气活血方治疗小儿脾肾气虚型肾病综合征的临床疗效显著,能够明显改善患儿肾功能,值得在临床上推广应用。

Clinical Efficacy of Yiqi Huoxue Decoction in the Treatment of Children with Spleen and Kidney Deficiency Type Nephrotic Syndrome

ABSTRACT Objective: To study the clinical efficacy of Yiqi Huoxue Decoction in the treatment of children with spleen and kidney deficiency type nephrotic syndrome. Methods: A total of 80 children with spleen and kidney deficiency type nephrotic syndrome in our hospital from June 2014 to October 2016 were enrolled in this study. The subjects were divided into control group (n=40) and treatment group (n=40) according to the random number table method. The control group was treated with prednisone, and the treatment group was treated with prednisone combined with Yiqi Huoxue Decoction, the two groups were treated for 4 months. The clinical efficacy of the two groups were evaluate. The 24h proteinuria,total cholesterol (TC), plasma albumin (Alb), and renal function parameters including blood urea nitrogen (BUN), serum creatinine (Scr),and serum creatinine clearance (Ccr) of the two groups before and after treatment were compared. Results: The total effective rate of the treatment group was 95.00%, which was significantly higher than 67.50% of the control group, the difference was statistically significant(P<0.05). The 24h proteinuria, TC, BUN and Scr of the two groups after treatment were significantly lower than before treatment, the Alb, Ccr of the two groups were significantly higher than before treatment, and above indexes in treatment group were better than the control group,the differences were statistically significant(P<0.05). Conclusion: Yiqi Huoxue Decoction have good clinical efficacy in the treatment of children with spleen and kidney deficiency type nephrotic syndrome,which can obviously improve children renal function, and is worthy of clinical application.