血浆hs-CRP和Hcy水平与血管性痴呆患者认知功能的关系

目的:探讨血浆超敏C反应蛋白(hs-CRP)和同型半胱氨酸(Hcy)水平与血管性痴呆(VD)患者认知功能的相关性。方法:回顾性分析2011年12月-2014年7月间我院100例脑梗死住院患者的临床资料,按诊断结果,将患者分为VD组55例和非VD组45例,另选取同期50例健康体检者为对照组。检测并比较3组血浆hs-CRP和Hcy水平,采用简易精神状态速检表(MMSE)对VD组进行痴呆程度分类,分析其与血浆hs-CRP和Hcy的相关性。结果:血浆Hcy与hs-CRP在3组间差异有统计学意义(P0.05),且VD组、非VD组均显著高于对照组,VD组显著高于非VD组,差异均有统计学意义(P0.05)。随着痴呆程度的加重,MMSE评分逐渐降低,血浆hs-CRP与Hcy水平则逐渐升高,差异有统计学意义(P0.05)。经相关性分析发现,MMSE评分和血浆hs-CRP与Hcy水平均呈负相关(r=-0.672,-0.703,P0.05)。结论:血浆hs-CRP与Hcy水平与VD患者的认知功能负相关,临床加强对两指标的检测对VD的诊断及防治有着重要的临床意义。

Relationship between the Levels of Plasma Hcy and hs-CRP and Cognitive Function in Patients with Vascular Dementia

ABSTRACT Objective: To study the correlation between the leves of plasma hypersensitive C-reactive protein(hs-CRP) and plasma homocysteine(Hcy) and cognitive function in patients with vascular dementia(VD). Methods: The clinical data of 100 cases of hospital- ized patients with cerebral infarction were retrospectively analyzed from December 2011 to July 2014, they were divided into VD groups 55 cases, and non-VD groups 45 cases according to diagnostic criteria, selected 50 cases of healthy persons in the same period as the con- trol group. Detected and compared plasma hs-CRP and Hcy levels in three groups, used mini mental state examination(MMSE) to classify the degree in VD group, and analyzed its correlation with plasma Hcy and hs-CRP. Results: Plasma Hcy and hs-CRP among 3 groups had significant difference(P<0.05), and non-VD and VD group were significantly higher than the control group, VD group was significantly higher than the non-VD group, which were significant differences(P<0.05). As the degree of dementia increased and the MMSE score de- creased and the plasma levels of plasma hs-CRP and Hcy levels were increased gradually, which was statistically significant difference(P<0.05). Correlation analysis found that the MMSE score negatively correlated with the plasma Hcy and hs-CRP (r=-0.672,-0.703, P<0.05). Conclusion: Plasma Hcy and hs-CRP are negatively correlated with cognitive function in patients with VD, detecting these two in- dexes is important significance for clinical diagnosis,prevention and treatment of VD.