翼状胬肉切除联合自体角膜缘干细胞移植术治疗翼状胬肉的临床疗效分析

目的:研究翼状胬肉切除术联合自体角膜缘干细胞移植治疗翼状胬肉的临床效果。方法:将2010年3月-2015年3月本院收治的105例翼状胬肉患者随机分为观察组和对照组。观察组患者53例,行翼状胬肉切除术联合自体角膜缘干细胞移植;对照组患者50例,行单纯翼状胬肉切除术。比较两组患者手术一般资料、手术前后视力水平、散光程度以及术后3个月和6个月的复发率。结果:术后,观察组角膜上皮修复时间、不适症状持续时间、住院时间均短于对照组;术后视力恢复情况、散光改善程度优于对照组;术后3个月和6个月治愈率显著高于对照组;而观察组术后并发率低于对照组,差异均有统计学意义(P0.05)。结论:翼状胬肉切除术联合自体角膜缘干细胞移植疗效显著、术后复发率低。

Analysis of the Clinical Efficacy of Pterygium Excision Combined with Autologous Limbal Stem Cell Transplantation in the Treatment of Pterygium

ABSTRACT Objective: To explore the clinical efficacy of pterygium excision combined with autologous limbal stem cell transplan- tation in the treatment of pterygium. Methods: From Mar 2010 to Mar 2015, 105 patients with pterygium in our hospital were randomly divided into the observation group and the control group. 53 patients in the observation group were treated with pterygium excision com- bined with autologous limbal stem cell transplantation and 50 patients in the control group were treated with simple pterygium excision. The general situation during the perioperation, visual acuity and astigmatism degree before and after surgery, curative rates and recur- rence rate were compared between two groups. Results: The cormeal epithelial healing time, duration of unwell symptoms and hospital stay of observation group were shorter than those of the control group(P<0.05); the visual acuity and astigmatism degree after surgery of observation group were significantly better than those of the control group(P<0.05); the curative rates of observation group at 3 months and 6 months after surgery were significantly higher than those of the control group and the recurrence rate of observation group was lower than that of the control group(P<0.05). Conclusion: Pterygium excision combined with autologous limbal stem cell transplantation was effective in the treatment of Pterygium with lower recurrence rate.