肺动脉高压动物模型的相关研究进展

肺动脉高压动物模型旨在模拟人类疾病特征,是研究者探索该疾病相关病理生理学机制及其治疗措施的重要工具。经典的肺动脉高压动物模型包括药物型、低氧型、手术型等,进来也出现一些新的模型,但这些动物模型都存在着不同的缺陷,不能很好地全面模拟人体肺动脉高压的特征。本文归纳总结了经典的造模方法和近年来出现的新方法,并且分析了各种模型的优势及其局限性,力求为今后实验动物模型的建立提供合适的方向,使其能更好地符合人类疾病特征。

The Progress in the Animal Modeling of Pulmonary Arterial Hypertension

ABSTRACT: Animal models of pulmonary artery hypertension (PAH), aiming to simulate human characteristics of the disease, have contributed extensively to understanding the pathophysiology of PAH and the investigation of experimental treatments. The classi- cal models include monocrotaline models, chronic hypoxia model and so on, more new models were investigated in recent years. These animal models were not able to perfectly mimic human pathological characteristics of PAH because of the defect in different aspects. In this review, both typical and novel methods of PAH modeling were summarized and evaluated to provide a suitable guidance for the set- tlement of animal models which can meet human characteristics comprehensively.