良性前列腺增生患者外周血Th17和Treg细胞比率的变化 |
| |
引用本文: | 吴宗林,金 姝,童 平,耿 和,朱洪炜,唐 炯,张 涛,刘 翔,夏术阶. 良性前列腺增生患者外周血Th17和Treg细胞比率的变化[J]. 现代生物医学进展, 2017, 17(32): 6312-6314 |
| |
作者姓名: | 吴宗林 金 姝 童 平 耿 和 朱洪炜 唐 炯 张 涛 刘 翔 夏术阶 |
| |
作者单位: | 上海市普陀区人民医院 上海200060;上海交通大学附属第一人民医院 上海200080 |
| |
基金项目: | 上海市卫生与计划生育委员会课题基金项目(20134419);普陀区卫生系统学科带头人培养计划基金(普卫〔2012〕2号) |
| |
摘 要: | 目的:探讨良性前列腺增生患者外周血Th17和Treg细胞比率的变化。方法:选择33例良性前列腺增生患者及19例正常对照者为研究对象,采用流式细胞术检测和比较其外周血中T淋巴细胞亚群及Th17和Treg细胞占CD4~+T细胞的比率。结果:良性前列腺增生患者外周血Th17和Treg细胞占CD4~+T细胞的比率分别为1.58±0.71和1.76±0.83,Th17/Treg的比率为0.89±0.42。正常健康对照者外周血Th17和Treg细胞占CD4~+T细胞的比率分别为0.75±0.46和1.83±0.75,Th17/Treg的比率为0.41±0.32。良性前列腺增生患者外周血Th17占CD4~+T细胞的比率和Th17/Treg的比率明显高于正常健康对照者(P0.05)。结论:良性前列腺增生患者体内Th17细胞比率升高,Th17/Treg比率失衡,可能与良性前列腺增生的发生、发展有关。
|
关 键 词: | 前列腺增生;Th17细胞;Treg细胞;炎症 |
收稿时间: | 2017-03-08 |
修稿时间: | 2017-03-31 |
Changes of Th17 and Treg Cell Ratio in the Peripheral Blood of Patients with Benign Prostatic Hyperplasia |
| |
Abstract: | ABSTRACT Objective: To investigate the ratio of Th17 cells and CD4+CD25-Foxp3+ regulatory T (Treg) cells in the peripheral blood of patients with benign prostatic hyperplasia (BPH). Methods: The peripheral whole blood was obtained from patients with BPH(n=33) and healthy controls (n=19). The percentage of Th17 and Treg cells were analyzed by flow cytometry. Results: The percentage of Th17 and Treg cells to CD4+T lymphocyte in patient with BPH was 1.58±0.71 and 1.76±0.83, respectively. The ratio of Th17 to Treg cells in patients with BPH was 0.89±0.42. The percentage of Th17 and Treg cells to CD4+T lymphocyte in the healthy controls were 0.75±0.46 and 1.83±0.75, respectively. The ratio of Th17 to Treg cells in the healthy controls was 0.41±0.32. The percentage of Th17 cells and ratio of Th17 to Treg cells were significantly increased in patients with BPH compared with healthy controls. Conclusion: The increased percentage of Th17 cells made the imbalance of Th17 to Treg cells in patients with BPH. The imbalance might be involved in the pathogenesis of BPH. |
| |
Keywords: | Benign prostatic hyperplasia Th17 cell Treg cells Inflammation |
本文献已被 CNKI 等数据库收录! |
| 点击此处可从《现代生物医学进展》浏览原始摘要信息 |
|
点击此处可从《现代生物医学进展》下载免费的PDF全文 |