纳络酮对脑梗塞患者血清降钙素原及叶酸水平及临床疗效的影响

目的:探讨纳络酮对脑梗塞患者血清降钙素原、叶酸水平及临床疗效的影响。方法:收集我院收治的110例急性脑梗死患者,随机分为实验组和对照组,每组55例。两组患者入院后根据实际情况给予抗血小板聚集,保护脑细胞,调控血压,脱水降低颅内压降颅压等对症治疗。对照组患者给予疏血通注射液6 m L+0.9%氯化钠注射液250 m L静脉滴注,1次/d;实验组患者在对照组基础上给予盐酸纳洛酮注射液3.2 g/d,+0.9%氯化钠注射液250 m L静脉滴注,治疗疗程为14 d。观察并比较两组患者治疗前后血清降钙素原(PCT)、同型半胱氨酸(Hcy)、叶酸水平以及临床治疗有效率。结果:与治疗前相比,两组患者治疗后的血清PCT、Hcy水平均显著下降,叶酸水平均明显升高,差异均具有统计学意义(P0.05);与对照组相比,实验组患者的PCT、Hcy水平较低,差异具有统计学意义(P0.05);与对照组相比,实验组患者治疗后的血清叶酸水平、临床治疗有效率均较高,差异具有统计学意义(P0.05)。结论:纳络酮能够显著提高脑梗塞患者的临床疗效,可能与其减轻炎症反应,降血清Hcy水平,升高血清叶酸水平有关。

Effect of Naloxone on the Serum Level of Calcitonin, Folic Acid and Clinical Efficacy of Patients with Cerebral Infarction

ABSTRACT Objective: To investigate the effect of naloxone on the serum calcitonin, folic acid levels and clinical effect of patients with cerebral infarction. Methods: 110 cases of acute cerebral infarction were randomly divided into the experimental group and control group, 55 cases in each group. The patients were given anti platelet aggregation, protection of brain cells, regulation of blood pressure, dehydration and reduction of intracranial pressure drop intracranial pressure and other symptomatic treatment after admission according to the actual situation. The Control group was treated with Shuxuetong injection 6 mL+0.9% chloride sodium injection 250 mL intravenous injection, 1 times/d; patients in the experimental group was given naloxone hydrochloride injection 3.2 g/d +0.9% chloride sodium injec- tion 250 mL intravenous injection based on the control group, treatment lasted for 14 days. The serum calcitonin (PCT), homocysteine (Hcy), folic acid levels and the clinical treatment efficiency of two groups were observed and compared before and after the treatment . Results: Compared with before treatment, the serum PCT, Hcy levels of two groups were significantly decreased after treatment (P<0.05) the folate levels of two groups were significantly increased after treatment (P<0.05); compared with the control group, the PCT, Hcy lev- els were obviously lower of the patients in experimental group (P<0.05), while the serum folic acid level and clinical effective rate were higher of the patients in experimental group (P<0.05). Conclusion: Naloxone could significantly improve the clinical efficacy of patients with cerebral infarction, which might be related to the decrease of inflammatory reaction, serum Hcy and folic acid levels.