肺炎支原体肺炎患儿外周血白介素的表达与肺功能变化的相关性

目的:探讨肺炎支原体(MPP)肺炎患儿外周血中IL-10、IL-17的表达水平与肺功能变化的相关性。方法:选取70例肺炎支原体肺炎患儿为研究对象,以是否有哮鸣音分为喘息组和非喘息组,以30例健康儿童为对照组,空腹采血5ml,分离血清,ELISA检测血清中IL-10、IL-17的表达水平,肺功能检测仪检测受检者的第一秒用力呼气容积(PEV1),最大呼气流量(PEF),用力肺活量(FEV1/FVC)。结果:喘息组中IL-10的表达水平与对照组相比差异显著(P0.05),喘息组中IL-10的表达水平与非喘息组相比差异显著(P0.05),喘息组中IL-17的表达水平与对照组相比差异显著(P0.05),喘息组中IL-17的表达水平与非喘息组相比差异显著(P0.05)。喘息组和非喘息组中IL-10水平均低于对照组,喘息组和非喘息组中IL-17水平均高于于对照组。非喘息组较喘息组PEV1、PEF、PVE1/FVC值高,差异显著(P0.05)。肺炎支原体肺炎患儿血清中的IL-10的水平与PEV1、PEF、PVE1/FVC呈正相关,肺炎支原体肺炎患儿血清中的IL-17的水平与PEV1、PEF、PVE1/FVC呈负相关。结论:肺炎支原体肺炎患儿血清中IL-10、IL-17的表达水平与肺功能密切相关。

Correlation between Lung Function and Peripheral Interleukin Expression of Mycoplasma Pneumonia Children

ABSTRACT Objective: To investigate the correlation between IL-10 and Il-17 expression levels in Mycoplasma pneumoniae pneu- monia (MPP) and lung function. Methods: 70 patients were included in this study. According to wheezing or not, they were divided into wheezing group and non-wheezing group. Another 30 healthy children were taken as a control group. After taking fasting blood 5ml, the serum IL-10 and IL-17 expression levels were detected by ELISA. The forced expiratory volume in one second (PEV1), peak expiratory flow (PEF) and forced vital capacity (FEV1 / FVC) of all subjects were detected. Results: The IL-10 expression level of the wheezing group were significantly different with that of the control group (P<0.05) and that of the non-wheezing group (P<0.05). The IL-17 expres- sion level of the wheezing group also had significant difference (P<0.05) with that of the control group and non-wheezing group (P<0.05). The IL-10 expression levels of wheezing and non-wheezing group all were lower than that of the control group. Whereas the IL-17 expression levels of wheezing and non-wheezing group all were higher than that in the control group. In addition, patients in wheezing group had higher PEV1, PEF, PVE1/FVC values than those in non-wheezing group, with significant difference (P<0.05). The serum level of IL-10 expression of Mycoplasma pneumonia patients was positively correlated with PEV1, PEF and PVE1/FVC, while the serum level of IL-17 expression of Mycoplasma pneumonia patients was negatively correlated with PEV1, PEF and PVE1/FVC. Conclusion: The serum levels of IL-17 and IL-10 expression of Mycoplasma pneumonia children had close correlation with their pulmonary function.